Decreased Fc fucosylation aligns with enhanced RSV-specific antibody functionality in adults compared to young children
Our data provide a detailed overview of similarities and differences between RSV-specific antibodies in children and adults. This information will support the ongoing quest for correlates of protection and the design of future vaccination strategies in different target populations.
Authors
- Gestur Vidarsson (ORCID: https://orcid.org/0000-0001-5621-003X)
- Anne T. Gelderloos (ORCID: https://orcid.org/0000-0002-7507-7622)
- Anke J. Lakerveld (ORCID: https://orcid.org/0000-0002-4386-3995)
- Wenjun Wang (ORCID: https://orcid.org/0000-0001-7781-9856)
- Nynke Y. Rots (ORCID: https://orcid.org/0000-0002-7170-7826)
- Puck B. van Kasteren (ORCID: https://orcid.org/0000-0003-4369-6055)
- Rutger M. Schepp (ORCID: https://orcid.org/0000-0003-3180-1807)
- Manfred Wuhrer (ORCID: https://orcid.org/0000-0002-0814-4995)
- Jan Nouta
- Robert S. van Binnendijk
- Steinar Gijze (ORCID: https://orcid.org/0009-0005-0982-7658)
Institutions
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Sanquin (NL)
- Netherlands Metabolomics Centre (NL)
- National Institute for Public Health and the Environment (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1038/s43856-025-01262-2
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universiteit Utrecht
- Ministerie van Volksgezondheid, Welzijn en Sport
- Leids Universitair Medisch Centrum
- National Institutes of Health