Enantioselective synthesis of <i>O</i> , <i>O</i> -acetal-fused tetracyclic scaffolds with fluorinated tetrasubstituted centers <i>via</i> fluorine-assisted asymmetric induction
An asymmetric cascade reaction of fluorinated 1,3-diketones and dioxopyrrolidines achieves the synthesis of fluorinated O , O -acetal-fused tetracyclic scaffolds and clarifies fluorine's H-bond regulatory function.
Authors
- Yuzhen Chen (ORCID: https://orcid.org/0000-0002-3391-8841)
- Yongbo Xue
- Huicai Huang (ORCID: https://orcid.org/0000-0002-8813-1499)
- Jialiang Qin (ORCID: https://orcid.org/0000-0002-6513-9447)
- Guohui Zeng (ORCID: https://orcid.org/0000-0001-9405-6563)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Guangxi Zhuang Autonomous Region Health and Family Planning (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1039/d5qo01486g
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00