Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults
With a rising incidence globally, there is need to address a basic deficiency, namely, the lack of a clear definition of sporadic early-onset invasive solid organ cancers in adults. This manuscript discusses this need to have a unified understanding of what constitutes sporadic early-onset cancers in adults based on (epi)genetic, biological, and environmental influences with an aim to motivate clinicians and scientists to think about these cancers from a broader perspective when developing their own research programs.
Authors
- Cathy Eng (ORCID: https://orcid.org/0000-0003-2335-0612)
- Bhawna Sirohi (ORCID: https://orcid.org/0000-0001-8093-1531)
- Irit Ben‐Aharon (ORCID: https://orcid.org/0000-0002-5839-5477)
- Kjetil Søreide (ORCID: https://orcid.org/0000-0001-7594-4354)
- Savio George Barreto (ORCID: https://orcid.org/0000-0002-4999-5657)
- Stephen J. Pandol (ORCID: https://orcid.org/0000-0003-0818-6017)
- Shailesh V Shrikhande
Institutions
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- Flinders University (AU)
- Technion – Israel Institute of Technology (IL)
- Homi Bhabha National Institute (IN)
- Vanderbilt University (US)
- Stavanger University Hospital (NO)
- Rambam Health Care Campus (IL)
- Flinders Medical Centre (AU)
- Adelaide Institute for Sleep Health (AU)
- Medical Research Foundation (GB)
- Vanderbilt-Ingram Cancer Center
- University of Bergen (NO)
Publication Details
- Journal
- Oncology and Therapy
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1007/s40487-025-00405-8
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00