Integration of spatial and single-cell transcriptomic analysis uncovers cellular and molecular alterations in the hypertensive brain
This study provides a comprehensive spatial transcriptomic atlas of the hypertensive brain, uncovering multidimensional molecular mechanisms underlying CNS-mediated blood pressure regulation. These results advance our understanding of neurogenic hypertension and may inform future diagnostic and therapeutic strategies.
Authors
- Junfa Li (ORCID: https://orcid.org/0000-0002-1930-9724)
- Jiang‐Shan Tan (ORCID: https://orcid.org/0000-0001-8154-674X)
- Luyun Fan
- Zhiqin Wang (ORCID: https://orcid.org/0000-0002-1708-7689)
- Jiali Fan (ORCID: https://orcid.org/0000-0002-6371-2377)
- Haizeng Zhang (ORCID: https://orcid.org/0000-0003-1433-3482)
- Zhigang Cai (ORCID: https://orcid.org/0009-0003-2416-9951)
- Jun Cai (ORCID: https://orcid.org/0000-0002-8928-9570)
- Zhenzhen Chen (ORCID: https://orcid.org/0000-0001-9919-3997)
- Cui Liu (ORCID: https://orcid.org/0000-0002-4102-096X)
- Qiannan Gao
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Beijing Anzhen Hospital (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.lfs.2025.124107
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81