Umbelliferone preserves skin epidermal barrier integrity in diabetes-induced keratinocytes by regulating actin dynamics and suppressing ROS-mediated apoptosis
Umbelliferone preserves epidermal barrier integrity by strengthening cell-cell junctions, enhancing hydration, promoting cell migration, and providing protection against oxidative stress and apoptosis. These findings suggest the therapeutic potential of umbelliferone in managing and preventing diabetic skin complications.
Authors
- Min‐Kyung Kang (ORCID: https://orcid.org/0000-0002-9461-9220)
- Young-Hee Kang
- Dong‐Yeon Kim (ORCID: https://orcid.org/0000-0001-6169-4518)
Institutions
- Gyeongguk National University (KR)
- Hallym University (KR)
Publication Details
- Journal
- Nutrition and Diabetes
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1038/s41387-025-00407-5
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea