Pharmaceutical Compatibility of Tissue Plasminogen Activator and DNase

Our findings demonstrate that tPA and DNase are pharmaceutically compatible when mixed and diluted in normal saline. This supports the feasibility of concurrent intrapleural administration, which may reduce labor intensity, improve protocol adherence, and lower the risk of iatrogenic infections in patients with pleural infections.

Authors

I.H. van der Sijs
Rogier A.S. Hoek (ORCID: https://orcid.org/0000-0003-2165-3222)
M. Hassanzai
J.F. Frencken

Institutions

Erasmus MC (NL)

Publication Details

Journal: Respiration
Published: 2025-11-24
DOI: https://doi.org/10.1159/000549731
Primary Topic: Protease and Inhibitor Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Pharmaceutical Compatibility of Tissue Plasminogen Activator and DNase

I.H. van der Sijs, Rogier A.S. Hoek, M. Hassanzai, J.F. Frencken

Nov 24, 2025

Respiration

Protease and Inhibitor Mechanisms

article

Pharmaceutical Compatibility of Tissue Plasminogen Activator and DNase

I.H. van der Sijs, Rogier A.S. Hoek, M. Hassanzai, J.F. Frencken

November 24, 2025article en

Abstract

Respiration

Erasmus MC (NL)

Openalex Percentile: Top 56%

Protease and Inhibitor Mechanisms

DOI Open Access PDF OpenAlex

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Pharmaceutical Compatibility of Tissue Plasminogen Activator and DNase — I.H. van der Sijs, Rogier A.S. Hoek, et al. · Respiration (2025) | TGRS Research Map | TGRS