The human umbilical cord–mesenchymal stem cell secretome regulates hair growth and cycle transition by promoting methylthioadenosine synthesis via the PI3K/AKT/mTOR pathway
SCT promoted hair growth, thickening, and the hair follicle cycle via the PI3K/AKT/mTOR signaling pathway. This research provides a basis for the application of cell-free alternatives in hair care and hair loss prevention.
Authors
- Xueer Wang (ORCID: https://orcid.org/0000-0001-9391-2911)
- Qimei Chen (ORCID: https://orcid.org/0000-0003-2497-8911)
- Min Zhang (ORCID: https://orcid.org/0000-0001-5812-9518)
- Jianyuan Huang (ORCID: https://orcid.org/0009-0005-4088-3084)
- Yarui Zhang
- Yong Miao (ORCID: https://orcid.org/0000-0003-4254-0673)
- Lin Zhang (ORCID: https://orcid.org/0000-0002-8249-7174)
- Lingwei Bu
- Shan Zhao
- Xinyu Yang (ORCID: https://orcid.org/0009-0009-1758-5221)
- Shenhua Wu
- Xunhong Xu
Institutions
- National Medical Products Administration (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s13287-025-04806-4
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00