Remodeling gut microbiota and enhancing SCFA production in mice: mechanisms of RS2 and arabinoxylan in ameliorating PCOS phenotypes
RS2 and AX alleviated PCOS phenotypes by enriching Ligilactobacillus, increasing SCFA production, and activating hepatic AMPK signaling. These findings highlight gut microbiota modulation and SCFA-driven metabolic pathways as therapeutic targets for PCOS. This study provides mechanistic insights into dietary fiber interventions for endocrine disorders.
Authors
- Xitao Li (ORCID: https://orcid.org/0000-0003-0803-7628)
- Yun Teh S. Liang (ORCID: https://orcid.org/0000-0002-2550-9220)
- Fu Chen (ORCID: https://orcid.org/0000-0001-7226-7554)
- Qingxia Huang (ORCID: https://orcid.org/0000-0001-8272-0201)
- Guishan Chen
- Xiaoping Yang (ORCID: https://orcid.org/0000-0002-4370-517X)
- Syuan-Hao Li
- Kwang‐Huei Lin (ORCID: https://orcid.org/0000-0002-5649-2222)
- Li‐Chun Lu (ORCID: https://orcid.org/0000-0001-8975-9491)
- Yangyang Hong
- Guoshu Yin (ORCID: https://orcid.org/0000-0002-5006-3486)
Institutions
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
Publication Details
- Journal
- BMC Endocrine Disorders
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12902-025-02107-8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00