Identification and Characterization of Alamandine-(1-5), a New Component of the Renin-Angiotensin System

Our data demonstrate that Ala-(1-5) is a newly identified peptide within the renin-angiotensin system, with strong blood pressure-lowering effects that vary in mechanisms of action among different tissues. Ala-(1-5) has distinct characteristics that differentiate it from the conventional renin-angiotensin system pathways responsible for reducing blood pressure.

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Publication Details

Journal
Circulation Research
Published
2025-11-12
DOI
https://doi.org/10.1161/circresaha.125.326174
Citations
2
Primary Topic
Renin-Angiotensin System Studies
Type
article
Field-Weighted Citation Impact
2.78
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article

Identification and Characterization of Alamandine-(1-5), a New Component of the Renin-Angiotensin System

Matheus F. Itaborahy, Pedro Alves Soares Vaz de Castro, Sérgio Scalzo, Daniel Campos Villela et al.
2 citations
Circulation Research
Renin-Angiotensin System Studies
2.78
article

Identification and Characterization of Alamandine-(1-5), a New Component of the Renin-Angiotensin System

Matheus F. Itaborahy, Pedro Alves Soares Vaz de Castro, Sérgio Scalzo, Daniel Campos Villela, Marco Antônio Peliky Fontes, Andréa Siqueira Haibara, Maria Cláudia Irigoyen, André Monteiro, Carolina Fonseca de Barros, Natália Ribeiro Cabacinha Nóbrega, Lucas Rodrigues‐Ribeiro, Amanda de Sá Martins de Bessa, Marcos Eliezeck, Bruno Durante da Silva, Ana Paula Davel, Sílvia Guatimosim, Gabriela da Silva Magalhães, A. Monteiro, Michael Bäder, Kamylle Silva Ferraz, Fernanda Ribeiro Marins, M. Fátima Leite, Sthefanie Chaves de Almeida Gonçalves, Carlos H. Castro, Luciano dos Santos Aggum Capettini, Ana Cristina Simões e Silva, Júlia Rezende Ribeiro, Ana Caroline Ventris de Godoy, Natalia V. Alenina, Nícia Pedreira Soares, Filipe Alex da Silva, João Batista Rodrigues Dutra, Daisy Motta‐Santos, Melissa Tainan Silva Dias, Thiago Verano‐Braga, Bruno Sanches, Maria José Campagnole‐Santos, Robson A.S. Santos, Ivana S. Lula, Maria Luiza Dias-Pinto, Uri Flegler Vieira-Machado, Isadora Zhong Liang Ferreira Feng, Amanda Silva, Danilo Augusto Alves Pereira, Leandro Eziquiel de Souza
article en
2 citations

Abstract

Our data demonstrate that Ala-(1-5) is a newly identified peptide within the renin-angiotensin system, with strong blood pressure-lowering effects that vary in mechanisms of action among different tissues. Ala-(1-5) has distinct characteristics that differentiate it from the conventional renin-angiotensin system pathways responsible for reducing blood pressure.

Circulation ResearchVol. 138(1)
Universidade Federal de Minas Gerais (BR), Helmholtz Association of German Research Centres (DE), Universidade de São Paulo (BR), Universidade Estadual de Campinas (UNICAMP) (BR), Max Delbrück Center (DE), Humboldt-Universität zu Berlin (DE), Department of Physiological Sciences (RU), Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR), Anna Needs Neuroblastoma Answers (US), German Centre for Cardiovascular Research (DE), Universidade Federal de Goiás (BR), Charité - Universitätsmedizin Berlin (DE), Lourdes University (US), University of Lübeck (DE)
Openalex Percentile: Top 8%
Renin-Angiotensin System Studies
2.78
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