Identification and Characterization of Alamandine-(1-5), a New Component of the Renin-Angiotensin System
Our data demonstrate that Ala-(1-5) is a newly identified peptide within the renin-angiotensin system, with strong blood pressure-lowering effects that vary in mechanisms of action among different tissues. Ala-(1-5) has distinct characteristics that differentiate it from the conventional renin-angiotensin system pathways responsible for reducing blood pressure.
Authors
- Matheus F. Itaborahy (ORCID: https://orcid.org/0000-0002-9461-8295)
- Pedro Alves Soares Vaz de Castro (ORCID: https://orcid.org/0000-0002-1183-7610)
- Sérgio Scalzo (ORCID: https://orcid.org/0000-0002-1496-878X)
- Daniel Campos Villela (ORCID: https://orcid.org/0000-0002-2510-9817)
- Marco Antônio Peliky Fontes (ORCID: https://orcid.org/0000-0003-4525-3565)
- Andréa Siqueira Haibara (ORCID: https://orcid.org/0000-0002-6783-8583)
- Maria Cláudia Irigoyen (ORCID: https://orcid.org/0000-0003-2097-3662)
- André Monteiro (ORCID: https://orcid.org/0000-0002-3632-9145)
- Carolina Fonseca de Barros (ORCID: https://orcid.org/0000-0002-1204-2596)
- Natália Ribeiro Cabacinha Nóbrega (ORCID: https://orcid.org/0000-0002-4524-0695)
- Lucas Rodrigues‐Ribeiro (ORCID: https://orcid.org/0000-0002-4011-637X)
- Amanda de Sá Martins de Bessa (ORCID: https://orcid.org/0000-0001-9806-4376)
- Marcos Eliezeck (ORCID: https://orcid.org/0000-0001-8942-6822)
- Bruno Durante da Silva (ORCID: https://orcid.org/0000-0003-3971-971X)
- Ana Paula Davel (ORCID: https://orcid.org/0000-0002-9862-4262)
- Sílvia Guatimosim (ORCID: https://orcid.org/0000-0001-8386-3722)
- Gabriela da Silva Magalhães (ORCID: https://orcid.org/0009-0009-0875-5591)
- A. Monteiro (ORCID: https://orcid.org/0009-0001-8334-1219)
- Michael Bäder (ORCID: https://orcid.org/0000-0003-4780-4164)
- Kamylle Silva Ferraz
- Fernanda Ribeiro Marins (ORCID: https://orcid.org/0000-0003-2735-5701)
- M. Fátima Leite (ORCID: https://orcid.org/0000-0001-9709-8865)
- Sthefanie Chaves de Almeida Gonçalves (ORCID: https://orcid.org/0000-0003-2210-0902)
- Carlos H. Castro (ORCID: https://orcid.org/0000-0002-9510-1124)
- Luciano dos Santos Aggum Capettini (ORCID: https://orcid.org/0000-0002-6487-9558)
- Ana Cristina Simões e Silva (ORCID: https://orcid.org/0000-0001-9222-3882)
- Júlia Rezende Ribeiro (ORCID: https://orcid.org/0009-0003-1761-7250)
- Ana Caroline Ventris de Godoy (ORCID: https://orcid.org/0000-0003-4789-1691)
- Natalia V. Alenina (ORCID: https://orcid.org/0000-0002-6071-5433)
- Nícia Pedreira Soares (ORCID: https://orcid.org/0000-0002-4699-4966)
- Filipe Alex da Silva (ORCID: https://orcid.org/0000-0002-1418-9591)
- João Batista Rodrigues Dutra (ORCID: https://orcid.org/0000-0002-9800-4979)
- Daisy Motta‐Santos (ORCID: https://orcid.org/0000-0002-3265-7838)
- Melissa Tainan Silva Dias (ORCID: https://orcid.org/0000-0002-3382-4255)
- Thiago Verano‐Braga (ORCID: https://orcid.org/0000-0002-7083-2588)
- Bruno Sanches (ORCID: https://orcid.org/0000-0002-9029-609X)
- Maria José Campagnole‐Santos (ORCID: https://orcid.org/0000-0001-9483-4206)
- Robson A.S. Santos (ORCID: https://orcid.org/0000-0001-8738-5852)
- Ivana S. Lula (ORCID: https://orcid.org/0009-0006-3987-5738)
- Maria Luiza Dias-Pinto (ORCID: https://orcid.org/0009-0007-2625-5836)
- Uri Flegler Vieira-Machado
- Isadora Zhong Liang Ferreira Feng (ORCID: https://orcid.org/0009-0001-3865-7126)
- Amanda Silva (ORCID: https://orcid.org/0009-0007-3226-8107)
- Danilo Augusto Alves Pereira (ORCID: https://orcid.org/0009-0001-4111-7008)
- Leandro Eziquiel de Souza (ORCID: https://orcid.org/0000-0001-8279-5422)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Helmholtz Association of German Research Centres (DE)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Max Delbrück Center (DE)
- Humboldt-Universität zu Berlin (DE)
- Department of Physiological Sciences (RU)
- Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR)
- Anna Needs Neuroblastoma Answers (US)
- German Centre for Cardiovascular Research (DE)
- Universidade Federal de Goiás (BR)
- Charité - Universitätsmedizin Berlin (DE)
- Lourdes University (US)
- University of Lübeck (DE)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1161/circresaha.125.326174
- Citations
- 2
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78