Front Cover: First Continuous‐Flow Intramolecular Dehydrative Friedel–Crafts Alkylation of Benzyl Alcohols in 1,1,1,3,3,3‐Hexafluoro‐2‐Propanol Catalyzed by HO‐Substituted Sulfonic Acid‐Functionalized Silica Gel (Eur. J. Org. Chem. 43/2025)

The Front Cover shows how, just as glass products of various shapes can be manufactured by blowing air into glass rods, it is now possible to synthesize diverse benzo-bicyclic compounds via a continuous-flow intramolecular dehydration Friedel Crafts alkylation reaction. This is achieved by passing an HFIP solution of 1-substituted ω-arylalkan-1-ols through a cartridge packed with hydroxy-substituted sulfonic acid functionalized silica gel (HO-SAS), which acts as a water-resistant immobilized Brønsted acid catalyst. More information can be found in the Research Article by K. Makino, M. Anada and co-workers (DOI: 10.1002/ejoc.202500861).