From nematode to Nobel: How community-shared resources fueled the rise of <i>Caenorhabditis elegans</i> as a research organism

Experimental organisms such as the nematode <i>Caenorhabditis elegans</i> are fundamental to biological discovery. The success of <i>C. elegans</i> research has been greatly enabled by infrastructure that allows thousands of scientists to share and access research materials and unpublished information efficiently. Here, we celebrate the worm by interweaving vignettes describing four Nobel Prize-winning discoveries with descriptions of how the major NIH-supported research resources-the <i>Caenorhabditis</i> Genetics Center, WormBase, and WormAtlas-provide invaluable support for all <i>C. elegans</i> research. The synergy between investigation and the availability of shared resources for the <i>C. elegans</i> community is a paradigm for all model organism research, and the continued support of such community research resources will be essential for maximizing impactful discoveries in the future.

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Journal
Proceedings of the National Academy of Sciences
Published
2025-11-24
DOI
https://doi.org/10.1073/pnas.2522808122
Citations
1
Primary Topic
Genetics, Aging, and Longevity in Model Organisms
Type
article
Field-Weighted Citation Impact
0.95

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From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism

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From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism

Aric L. Daul, Nathan E. Schroeder, David H. Hall, Craig C. Mello, Paul W. Sternberg, Ann E. Rougvie, Andrew Z. Fire, Gary Ruvkun, Victor Ambros, Martin Chalfie, H. Robert Horvitz
article en
1 citations

Abstract

Experimental organisms such as the nematode <i>Caenorhabditis elegans</i> are fundamental to biological discovery. The success of <i>C. elegans</i> research has been greatly enabled by infrastructure that allows thousands of scientists to share and access research materials and unpublished information efficiently. Here, we celebrate the worm by interweaving vignettes describing four Nobel Prize-winning discoveries with descriptions of how the major NIH-supported research resources-the <i>Caenorhabditis</i> Genetics Center, WormBase, and WormAtlas-provide invaluable support for all <i>C. elegans</i> research. The synergy between investigation and the availability of shared resources for the <i>C. elegans</i> community is a paradigm for all model organism research, and the continued support of such community research resources will be essential for maximizing impactful discoveries in the future.

Proceedings of the National Academy of SciencesVol. 122(48)
California Institute of Technology (US), Albert Einstein College of Medicine (US), University of Minnesota (US), University of Illinois Urbana-Champaign (US), University of Massachusetts Chan Medical School (US), Massachusetts General Hospital (US), Institut thématique Génétique, génomique et bioinformatique (FR), Massachusetts Institute of Technology (US), Columbia University (US), Stanford University (US)
National Institutes of Health
Openalex Percentile: Top 20%
Genetics, Aging, and Longevity in Model Organisms
0.95
DOIOpen Access PDFOpenAlex
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