Development of a highly differentiated rat brain organoid model for exploring glioblastoma invasion dynamics and therapy
The rBOs serve as an effective target brain structure for studying GB invasion parameters and for evaluating therapeutic interventions. Their rapid development into mature brain tissue makes rBOs a valuable brain avatar system for studying tumor-host interactions.
Authors
- Gunnar Dittmar (ORCID: https://orcid.org/0000-0003-3647-8623)
- Carina Fabian (ORCID: https://orcid.org/0000-0002-2721-3052)
- Wenjing Zhou
- Frits Thorsen (ORCID: https://orcid.org/0000-0002-7762-3703)
- Petr V. Nazarov (ORCID: https://orcid.org/0000-0003-3443-0298)
- Boris Mihaljević
- Katharina Sarnow (ORCID: https://orcid.org/0000-0002-6091-5689)
- Magnar Bjørås (ORCID: https://orcid.org/0000-0001-8759-1170)
- Olivier Keunen (ORCID: https://orcid.org/0000-0003-2203-7026)
- Jakub Mieczkowski (ORCID: https://orcid.org/0000-0002-2091-012X)
- Anna Golebiewska (ORCID: https://orcid.org/0000-0002-4160-2521)
- Konrad Grützmann (ORCID: https://orcid.org/0000-0001-8942-0287)
- Yan Li
- Saverio Tardito (ORCID: https://orcid.org/0000-0002-5294-8683)
- Barbara Klink (ORCID: https://orcid.org/0000-0002-8753-8238)
- Barbara van Loon (ORCID: https://orcid.org/0000-0002-7597-207X)
- Halala Sdik Saed (ORCID: https://orcid.org/0009-0009-6200-8239)
- Taral R. Lunavat (ORCID: https://orcid.org/0000-0001-8198-1805)
- Simone P. Niclou (ORCID: https://orcid.org/0000-0002-3417-9534)
- Agnieszka Misztak (ORCID: https://orcid.org/0000-0001-5977-3532)
- Hrvoje Miletić (ORCID: https://orcid.org/0000-0002-5751-186X)
- Rolf Bjerkvig (ORCID: https://orcid.org/0000-0002-9622-7263)
- Shannon Sherwin Moreino
- Georgia Kanli (ORCID: https://orcid.org/0000-0001-8713-9838)
- Stephanie Schwab
- Elena Martínez-García (ORCID: https://orcid.org/0000-0003-2547-7916)
- Mingzhi Han (ORCID: https://orcid.org/0000-0001-8357-5974)
- Zhiyi Xue (ORCID: https://orcid.org/0000-0002-1357-202X)
- Jubayer A. Hossain (ORCID: https://orcid.org/0000-0002-6497-4061)
- J V Joesph
- Johannes Meiser (ORCID: https://orcid.org/0000-0002-9093-6210)
- Wenjie Li (ORCID: https://orcid.org/0000-0002-1413-0928)
- Jian Wang (ORCID: https://orcid.org/0000-0001-7620-6740)
- Xingang Li (ORCID: https://orcid.org/0000-0002-4066-0973)
- Yan Zhang
- Christian Jaeger
- Marzieh Bahador
Institutions
- Boston Children's Hospital (US)
- Shandong University (CN)
- Zimmer Biomet (Netherlands) (NL)
- University of Luxembourg (LU)
- Norwegian University of Science and Technology (NO)
- Haukeland University Hospital (NO)
- Nord University (NO)
- Comprehensive Cancer Center Vienna (AT)
- Luxembourg Institute of Health (LU)
- National Center for Tumor Diseases (DE)
- Medical Genetics Center (DE)
- Shandong Provincial Hospital (CN)
- Norwegian Womens Public Health Association (NO)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
- University of Bergen (NO)
- Gdańsk Medical University (PL)
- University of Split (HR)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1093/neuonc/noaf271
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- National Natural Science Foundation of China
- Norges Forskningsråd