Predictors of Successful Neoadjuvant Chemotherapy and Interval Cytoreductive Surgery in Management of Ovarian Cancer
In two data sets, the tumor chemosensitivity assessed by the KELIM (online calculator)<sup>29</sup> was a consistent significant predictor of three critical outcomes associated with successful ICS after NACT. The radiologic response was inconsistently associated with lower disease bulk. The <i>BRCA</i>/HRD status was not predictive of NACT efficacy. These outcomes may inform decisions and future chemosensitizing innovative strategies.
Authors
- Aurore Carrot (ORCID: https://orcid.org/0000-0002-8835-2865)
- Umberto Malapelle (ORCID: https://orcid.org/0000-0003-3211-9957)
- Félix Blanc‐Durand (ORCID: https://orcid.org/0000-0002-5277-1515)
- Alexandra Léary (ORCID: https://orcid.org/0000-0002-2043-2244)
- Olivier Colomban (ORCID: https://orcid.org/0000-0003-1671-3470)
- Carolina Maria Sassu (ORCID: https://orcid.org/0000-0002-1702-5859)
- Gwénaël Ferron (ORCID: https://orcid.org/0000-0002-8545-4700)
- Pierre Combe (ORCID: https://orcid.org/0000-0002-7321-7345)
- Domenica Lorusso (ORCID: https://orcid.org/0000-0003-0981-0598)
- Filippo Maria Capomacchia (ORCID: https://orcid.org/0000-0002-5509-4193)
- Alain Lortholary (ORCID: https://orcid.org/0000-0002-2585-6193)
- Éric Pujade-Lauraine (ORCID: https://orcid.org/0000-0002-0759-7263)
- Isabelle Laure Ray-Coquard (ORCID: https://orcid.org/0000-0003-2472-8306)
- Cláudia Marchetti (ORCID: https://orcid.org/0000-0001-7098-8956)
- Benoît You (ORCID: https://orcid.org/0000-0002-3177-8857)
- Anna Fagotti (ORCID: https://orcid.org/0000-0001-5579-335X)
- Adriana Ionelia Apostol (ORCID: https://orcid.org/0009-0008-4614-9261)
- Raffaella Ergasti (ORCID: https://orcid.org/0000-0002-5066-1419)
- Diana Giannarelli (ORCID: https://orcid.org/0000-0002-6085-1195)
- Giovanni Scambia (ORCID: https://orcid.org/0000-0003-2758-1063)
- Gian Franco Zannoni
- Pierre-Alexandre Just (ORCID: https://orcid.org/0000-0002-0458-4117)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Università Cattolica del Sacro Cuore (IT)
- Lyon College (US)
- Institut Gustave Roussy (FR)
- Agostino Gemelli University Polyclinic (IT)
- Assistance Publique Hôpitaux de Marseille (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Centre Léon Bérard (FR)
- Hôpital Européen (FR)
- Institut Claudius Regaud (FR)
- Arcagy Gineco (FR)
- Hôpital privé du Confluent (FR)
- Eau de Paris (France) (FR)
- University of Naples Federico II (IT)
- HCL Technologies (India) (IN)
Publication Details
- Journal
- JCO Oncology Practice
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1200/op-25-00469
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00