Disability Worsening Phenotypes in Multiple Sclerosis and Impact of Disease-Modifying Treatments
We identified 4 clinically relevant disability worsening phenotypes in relapse-onset MS, primarily driven by PIRA, with greater CNS involvement linked to early and rapid progression. Despite reliance on EDSS alone, these phenotypes may inform personalized treatment and response assessment.
Authors
- Pietro Osvaldo Luigi Annovazzi (ORCID: https://orcid.org/0000-0003-0279-0707)
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Diana Ferraro (ORCID: https://orcid.org/0000-0003-4818-3806)
- Franco Granella
- Carla Tortorella (ORCID: https://orcid.org/0000-0001-9037-7300)
- María Trojano (ORCID: https://orcid.org/0000-0002-6329-8946)
- Alessandra Lugaresi (ORCID: https://orcid.org/0000-0003-2902-5589)
- Emilio Portaccio (ORCID: https://orcid.org/0000-0002-9662-1762)
- Alessia Di Sapio (ORCID: https://orcid.org/0000-0002-5575-7567)
- Maria Pia Amato (ORCID: https://orcid.org/0000-0003-3325-3760)
- Pietro Iaffaldano (ORCID: https://orcid.org/0000-0003-2308-1731)
- Giovanna De Luca (ORCID: https://orcid.org/0000-0002-7693-2256)
- Ermelinda De Meo (ORCID: https://orcid.org/0000-0001-5531-1111)
- Matteo Foschi (ORCID: https://orcid.org/0000-0002-0321-7155)
- Marta Simone (ORCID: https://orcid.org/0000-0003-4381-4613)
- Ilaria Addazio
- Raffaello Bonacchi (ORCID: https://orcid.org/0000-0003-3406-2704)
- Francesco Patti (ORCID: https://orcid.org/0000-0002-6923-0846)
- Silvia Romano (ORCID: https://orcid.org/0000-0003-0499-8843)
- Carlo Pozzilli (ORCID: https://orcid.org/0000-0002-6360-4798)
- Maria Assunta Rocca (ORCID: https://orcid.org/0000-0003-2358-4320)
- Giacomo Lus (ORCID: https://orcid.org/0000-0002-9457-1124)
- Eleonora E. Cocco (ORCID: https://orcid.org/0000-0002-3878-8820)
- Federico Camilli
- Vincenzo Brescia Morra (ORCID: https://orcid.org/0000-0003-0462-9618)
- Marika Vianello (ORCID: https://orcid.org/0009-0006-0864-7230)
- Paola Perini (ORCID: https://orcid.org/0009-0008-9628-1180)
- M. Betti (ORCID: https://orcid.org/0000-0001-6621-3971)
- Simone Guerrieri
Institutions
- University of Parma (IT)
- Vita-Salute San Raffaele University (IT)
- Queen Mary University of London (GB)
- Policlinico Umberto I (IT)
- Associazione Italiana Sclerosi Multipla (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- ATS Sardegna (Italy) (IT)
- Ospedale Santa Maria (IT)
- Don Carlo Gnocchi Foundation (IT)
- Federico II University Hospital (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Tecnologie Avanzate (Italy) (IT)
- Ca' Foncello Hospital (IT)
- Azienda Ospedale - Università Padova (IT)
- Ospedale SS. Annunziata (IT)
- Ospedale San Luigi Gonzaga (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Florence (IT)
- University College London (GB)
- University of Bari Aldo Moro (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Neurology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1212/wnl.0000000000214408
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47