Weifuchun alleviates MNNG-induced chronic atrophic gastritis by improving the gastric and intestinal microbiota homeostasis
WFC alleviated PLGC by regulating the balance of gastrointestinal microbiota and influencing the IL-6/JAK1/STAT3 pathway, revealing the potential connection between gastrointestinal microbiota and CAG progression. This study is the first to link gastrointestinal microbiota homeostasis and IL-6/JAK1/STAT3 pathway, providing novel insights into WFC's multi-targeted therapeutic mechanism on CAG.
Authors
- Yong Sang Hong (ORCID: https://orcid.org/0000-0001-5672-0072)
- Jiaojiao Yang
- Haiying Wang (ORCID: https://orcid.org/0000-0001-9366-7661)
- Yingying Chen (ORCID: https://orcid.org/0000-0002-5049-8092)
- Shenbao Wu (ORCID: https://orcid.org/0000-0002-4704-6642)
- X Lou
- Ping Feng
Institutions
- Sir Run Run Shaw Hospital (CN)
- Yiwu Science and Technology Research Institute (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1371/journal.pone.0333375
- Citations
- 1
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01