Combination therapy with 3-Hydroxybenzaldehyde and Albendazole modulates mitochondrial protein expression in astrocytes after Angiostrongylus cantonensis infection
These results suggest that the combination of 3-HBA and albendazole downregulates astrocyte activation and VDAC1/MCU-associated mitochondrial pathways following A. cantonensis infection. These findings support the use of 3-HBA as a promising adjuvant to albendazole in the treatment of angiostrongyliasis.
Authors
- Yihao Huang (ORCID: https://orcid.org/0009-0002-1207-7905)
- Shih-Hsin Chang (ORCID: https://orcid.org/0000-0003-2821-7095)
- Chien-Ju Cheng
- Kuang-Yao Chen (ORCID: https://orcid.org/0000-0002-9783-3775)
- Yu‐Chi Chou (ORCID: https://orcid.org/0000-0002-0783-1339)
- Chyi‐Liang Chen (ORCID: https://orcid.org/0000-0003-4591-0924)
- Yi-Hsuan Lin (ORCID: https://orcid.org/0009-0008-0072-2990)
Institutions
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- Mackay Medical University (TW)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1371/journal.pntd.0013773
- Primary Topic
- Mollusks and Parasites Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00