Safety and efficacy of stapokibart, an anti-interleukin-4 receptor α monoclonal antibody, in children aged 6–11 years with moderate-to-severe atopic dermatitis: an open-label single-arm phase Ib/IIa trial
Stapokibart shows potential in improving disease outcomes and appears to be well tolerated in children aged 6-11 years with moderate-to-severe AD. Larger controlled studies are needed to confirm long-term benefits.
Authors
- Zhimiao Lin (ORCID: https://orcid.org/0000-0002-3240-1998)
- Qian Qiufang
- Guohong Hu (ORCID: https://orcid.org/0000-0002-2980-5166)
- Yangfeng Ding
- Xu Li (ORCID: https://orcid.org/0009-0005-9184-5985)
- Bin Yang (ORCID: https://orcid.org/0000-0002-1700-2817)
- Zigang Xu (ORCID: https://orcid.org/0000-0001-8645-1854)
- Lin Ma (ORCID: https://orcid.org/0000-0001-7625-9842)
- Mutong Zhao (ORCID: https://orcid.org/0000-0002-1885-4579)
- Liming Wu (ORCID: https://orcid.org/0000-0002-5738-0468)
- Yufeng Xu
- Yingmin Jia (ORCID: https://orcid.org/0000-0001-8909-9315)
- Bo Chen (ORCID: https://orcid.org/0000-0001-6917-8833)
- Yanqiu Huang (ORCID: https://orcid.org/0000-0002-0962-6785)
- Hua Wang (ORCID: https://orcid.org/0000-0001-5938-0851)
- Yusong Xu (ORCID: https://orcid.org/0009-0004-8161-4983)
- Wei Zhu (ORCID: https://orcid.org/0009-0001-4533-7067)
- Qin Ran
Institutions
- Chengdu Medical College (CN)
- Chengdu Women's and Children's Central Hospital (CN)
- Jiangxi Chest Hospital (CN)
- Hunan Children's Hospital (CN)
- Beijing Children’s Hospital (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shanghai Skin Disease Hospital (CN)
- Shanghai Children's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Shandong First Medical University (CN)
- Southern Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1093/bjd/ljaf455
- Citations
- 2
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.01