An Interdisciplinary Laboratory Module on Glycine-Induced Rapid Radical Polymerization: Injectable PHEMA Hydrogels for Chemical Education

This laboratory experiment introduces undergraduate students to an interdisciplinary approach combining polymer chemistry, materials science, and biomedical engineering through the synthesis and characterization of injectable poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels. The experiment employs a glycine-induced redox radical polymerization method to prepare hydrogels under physiological conditions without organic solvents or toxic cross-linkers. Students explore structure–property relationships by evaluating the influence of glycine concentration on gelation time, network structure, and mechanical properties using Fourier transform infrared (FT-IR) spectroscopy, rheological analysis, and tensile testing. The experiment also includes an injectability test, allowing students to experience in situ hydrogel formation. This hands-on module enhances students’ understanding of radical polymerization kinetics, network interactions, and hydrogel mechanics while promoting scientific inquiry and interdisciplinary thinking. The module has been successfully implemented at Sichuan Normal University, demonstrating strong pedagogical outcomes in knowledge acquisition, technical skill development, and research enthusiasm. This experiment offers a scalable and cost-effective strategy for incorporating emerging biomaterial concepts into undergraduate chemistry education.