Intratumour ploidy heterogeneity and clonal evolution in hepatocellular carcinoma
Modification of ploidy play a substantial role in cancer genome evolution. In this study, we created a new digital pathology method to accurately measure the hepatocyte ploidy profile of HCC. This powerful tool reveals three distinct tumour types: diploid (DP), hyperploid (HP), and mixed diploid/hyperploid (DP/HP) HCCs. By clearly defining these groups, we gain crucial, new insights into the "branching" evolution of HCC tumours. This study should pave the way for novel diagnostic and therapeutic strategies.
Authors
- Pierre Cordier
- Théo Z. Hirsch (ORCID: https://orcid.org/0000-0003-4428-2997)
- Sandrine Imbeaud (ORCID: https://orcid.org/0000-0001-8439-6732)
- Patricia de la Cruz‐Ojeda (ORCID: https://orcid.org/0000-0002-9867-9191)
- Christophe Klein (ORCID: https://orcid.org/0000-0001-8015-287X)
- Isabelle Galy–Fauroux (ORCID: https://orcid.org/0000-0001-8477-051X)
- Jessica Zucman‐Rossi (ORCID: https://orcid.org/0000-0002-5687-0334)
- Chantal Desdouets (ORCID: https://orcid.org/0000-0002-1955-8915)
- Julien Caldéraro (ORCID: https://orcid.org/0000-0002-5370-0807)
- Lucie Poupel (ORCID: https://orcid.org/0000-0001-7015-8450)
- Stefano Caruso (ORCID: https://orcid.org/0000-0002-6319-3642)
- Long Pan
- Pascale Maillé
Institutions
- Inserm (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.jhep.2025.11.015
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32