Primary Intracranial Neuroendocrine Carcinoma Revealed by 18F-FDG PET/CT

Neuroendocrine carcinoma (NEC) is a rare and aggressive malignancy that most commonly arises from neuroendocrine cells in the gastrointestinal tract and lungs. Primary intracranial NEC is exceedingly rare, with limited cases reported in the literature. We present the FDG PET/CT imaging finding of a rare case of a large primary intracranial NEC involving the cerebral parenchyma, which appeared as a cystic-solid mass with intense FDG uptake in the irregular rim and solid component.