Kidney Transplantation–Induced Reduction in Myocardial Fibrosis and Modulation of Plasma Proteome: Results of a Pilot Study
KT leads to regression of interstitial myocardial fibrosis within 9 months, supporting a structural cardiac benefit of transplantation. Pretransplant proteomic signatures, particularly macrophage colony-stimulating factor, reflect underlying fibrotic burden and may serve as a predictive biomarker to monitor post-KT cardiac recovery.
Authors
- Anne M. Huml (ORCID: https://orcid.org/0000-0002-6224-0785)
- Aparna Padiyar
- Sudha K. Iyengar (ORCID: https://orcid.org/0000-0001-7488-250X)
- Sadeer G Al-Kindi (ORCID: https://orcid.org/0000-0002-1122-7695)
- Scott E. Janus (ORCID: https://orcid.org/0000-0003-0635-6131)
- Mirela Dobre (ORCID: https://orcid.org/0000-0002-9059-9998)
- Chen-Yu Liu (ORCID: https://orcid.org/0000-0002-4693-5667)
- Jordana Yahr (ORCID: https://orcid.org/0000-0002-8456-6014)
- Jeffrey R. Schelling (ORCID: https://orcid.org/0000-0003-3503-2208)
- Liangliang Zhang (ORCID: https://orcid.org/0000-0001-5986-2260)
- Shruti Ahlawat (ORCID: https://orcid.org/0000-0001-6752-6902)
- Mahboob U. Rahman
- Sanjay Rajagopalan
- Robert J. Gaivin
Institutions
- Cleveland Clinic (US)
- University Hospitals of Cleveland (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Case Comprehensive Cancer Center
- Case Western Reserve University (US)
Publication Details
- Journal
- Kidney Medicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.xkme.2025.101191
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00