Prognostic impact of restrictive ventilatory defects in chronic lung allograft dysfunction without restrictive allograft syndrome-like opacities: Stratification of emerging undefined and unclassified phenotypes
Non-RLO CLAD patients with restrictive ventilatory defects demonstrated significantly increased cumulative incidence of death (retransplantation as a competing risk), challenging the assumption that all non-RLO cases follow a favorable BOS-like prognosis. Pleural effusion was identified as a significant independent prognostic marker.
Authors
- Hiroya Ojiri (ORCID: https://orcid.org/0000-0002-5573-6299)
- Staci Gagne (ORCID: https://orcid.org/0000-0003-0529-7627)
- Takeshi Johkoh (ORCID: https://orcid.org/0000-0003-1237-2349)
- Yuki Ko (ORCID: https://orcid.org/0000-0003-1455-4453)
- Taiki Fukuda (ORCID: https://orcid.org/0000-0001-9173-738X)
- Hiroto Hatabu (ORCID: https://orcid.org/0000-0003-1436-2988)
- Mizuki Nishino (ORCID: https://orcid.org/0000-0003-0275-0502)
- Shu-Chi Tseng (ORCID: https://orcid.org/0000-0002-9671-9006)
- Lynette M. Sholl (ORCID: https://orcid.org/0000-0002-9532-9735)
- Yi Li (ORCID: https://orcid.org/0009-0001-5532-7161)
- David C. Christiani
- Y. Nakamura (ORCID: https://orcid.org/0000-0001-6709-2876)
Institutions
- Jikei University School of Medicine (JP)
- Brigham and Women's Hospital (US)
- Kyushu University (JP)
- Harvard University (US)
- Chang Gung University (TW)
- University of Michigan (US)
- Massachusetts General Hospital (US)
- Kansai Rosai Hospital (JP)
- Linkou Chang Gung Memorial Hospital (TW)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- JHLT Open
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.jhlto.2025.100445
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00