Palladium( <scp>ii</scp> )-catalysed intramolecular hydroamination of 3-alkynyltetrahydroquinolines to methanobenzo[ <i>b</i> ]azepines
The selective Pd(II)-catalysed intramolecular 5-<i>endo-dig</i> hydroamination of 3-alkynyltetrahydroquinolines was developed to give structurally novel sp<sup>3</sup>-rich methanobenzo[<i>b</i>]azepine heterocycles. The pendant functionalities of these densely functionalised products include a nitro substituent and a vinyl handle, which were accessible to synthetic modifications for further enhancement of the molecular complexity.
Authors
- Chi Bong Eric Chao (ORCID: https://orcid.org/0000-0003-1764-6548)
- Stephen G. Pyne (ORCID: https://orcid.org/0000-0003-0462-0277)
- Christopher Richardson (ORCID: https://orcid.org/0000-0002-5804-6322)
- Christopher J. T. Hyland (ORCID: https://orcid.org/0000-0002-9963-5924)
- Andrew J. Tague (ORCID: https://orcid.org/0000-0003-0561-4629)
- Lloyd R. Kellermann (ORCID: https://orcid.org/0009-0000-2082-2827)
Institutions
- University of Wollongong (AU)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1039/d5cc05479f
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00