Improved outcome prediction in large vessel occlusion stroke: A comparison of Tmax-based hypoperfusion ratios HIR10/4 and HIR10/6
Incorporating mildly delayed tissue (T<sub>max</sub> >4 s) may enhance the physiologic sensitivity of HIR. HIR<sub>10/4</sub> may be a potential prognostic biomarker; however, prospective validation is needed, and its standalone ability to discriminate binary outcomes remains limited.
Authors
- John Ta-Hsiang Tsiang (ORCID: https://orcid.org/0000-0001-5869-6408)
- Anthony W. Kam (ORCID: https://orcid.org/0000-0002-3012-136X)
- Ronak Jani (ORCID: https://orcid.org/0000-0002-5687-6488)
- Joseph C. Serrone (ORCID: https://orcid.org/0000-0001-6517-1212)
- Brandon Bond (ORCID: https://orcid.org/0000-0002-0101-4514)
- Andrew Pickles (ORCID: https://orcid.org/0009-0003-8748-2275)
- Amy Wozniak (ORCID: https://orcid.org/0000-0002-0670-3677)
- David Pasquale
- William Y. Shin
- Jeewon Chon
- Ashley Treanor
Institutions
- Loyola University Chicago (US)
- Loyola Medicine (US)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108504
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Loyola University Chicago
- National Institutes of Health