QbD assisted formulation, optimization and characterization of psoralen phytosome prepared through thin film hydration method

SL-based phytosomes improved psoralen dermal delivery by enhancing entrapment, penetration, and providing sustained release. These findings support phytosomal encapsulation as a promising topical delivery strategy for psoralen; however, direct bioavailability and <i>in vivo</i>/<i>ex vivo</i> validation are required to confirm therapeutic efficacy in psoriasis.