Dipeptidyl Peptidase 4 Restoration Facilitates Antitumor Immunity in KRAS-LKB1–Mutant Lung Cancer
LKB1 loss suppresses DPP4 expression in KL-NSCLC; however, restoring DPP4 expression in vitro promotes NK-cell recruitment, mitigating the immunosuppressive TME and enhancing the efficacy of anti-PD-1 therapy in KL models.
Authors
- Mizuki Homme (ORCID: https://orcid.org/0009-0006-1747-4028)
- Toshiyuki Tenma (ORCID: https://orcid.org/0009-0003-1209-661X)
- Ryohei Yoshida (ORCID: https://orcid.org/0000-0002-2959-9972)
- Hiraku Yanada (ORCID: https://orcid.org/0009-0009-9915-554X)
- Yusuke Mizukami (ORCID: https://orcid.org/0000-0002-1068-7024)
- Toshihiro Nagato (ORCID: https://orcid.org/0000-0001-8326-8296)
- Kyohei Oyama (ORCID: https://orcid.org/0000-0002-8478-4417)
- Shoichiro Tange (ORCID: https://orcid.org/0000-0002-2126-6938)
- Shunsuke Kitajima (ORCID: https://orcid.org/0000-0001-6532-2543)
- Takayuki Ohkuri (ORCID: https://orcid.org/0000-0002-6889-7809)
- David Allen Barbie (ORCID: https://orcid.org/0000-0002-5422-4275)
- Nobunari Sasaki (ORCID: https://orcid.org/0009-0009-4336-588X)
- Hiroya Kobayashi (ORCID: https://orcid.org/0000-0001-5222-8961)
- Kiichi Nitanai (ORCID: https://orcid.org/0009-0004-8653-7593)
- Yusuke Ono (ORCID: https://orcid.org/0000-0001-8385-5386)
- Takaaki Sasaki (ORCID: https://orcid.org/0000-0002-6505-8786)
- Yoshinori Minami (ORCID: https://orcid.org/0000-0002-5368-0527)
- Chie Mori (ORCID: https://orcid.org/0000-0002-4398-1086)
Institutions
- Sapporo Medical University (JP)
- Asahikawa Medical University (JP)
- Sapporo Higashi Tokushukai Hospital (JP)
- Dana-Farber Cancer Institute (US)
- Nishikawa Hospital (JP)
- Japanese Foundation For Cancer Research (JP)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0199
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00