Hypervalent Iodine(III) Carboxylates Enable Direct Radiosynthesis of <sup>18</sup> F-Labeled Aliphatic Sulfonyl Fluorides
Sulfur(VI) fluoride exchange (SuFEx) chemistry has enabled the widespread use of sulfur-fluoride compounds in diverse fields, particularly in positron emission tomography (PET) imaging. However, efficient methods for incorporating SO<sub>2</sub>-<sup>18</sup>F into aliphatic frameworks are lacking, limiting access to structurally diverse probes. Here, we report a direct <sup>18</sup>F-labeling strategy that converts aliphatic hypervalent iodine(III) carboxylates or carboxylic acids into alkyl-SO<sub>2</sub>-<sup>18</sup>F derivatives, expanding the PET imaging toolkit and enabling the development of new radiotracers.
Authors
- Yifan Shi (ORCID: https://orcid.org/0000-0002-1164-2469)
- Bo Yu (ORCID: https://orcid.org/0000-0003-2876-7425)
- Feng Xiong (ORCID: https://orcid.org/0000-0001-8383-5182)
- Chih‐Yang Huang (ORCID: https://orcid.org/0000-0003-2347-0411)
- Xiaoyun Deng (ORCID: https://orcid.org/0000-0002-2276-3143)
- Xiaohua Zhu (ORCID: https://orcid.org/0000-0003-0495-9510)
- Ziqiang Wang (ORCID: https://orcid.org/0000-0002-2979-9456)
- Jingfei Yang
- Yilin Yang
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1021/acs.orglett.5c04232
- Primary Topic
- Covalent Organic Framework Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00