A Novel Rabbit Model of Angle-Closure Glaucoma Via Ciliary Block and Elevated Trans-Lens Pressure Difference
We successfully developed a reproducible rabbit model in which ciliary block-induced trans-lens pressure difference acts as a pivotal mechanistic link to anterior chamber shallowing, angle closure, and sustained IOP elevation, recapitulating key features of human angle-closure glaucoma.
Authors
- Guangying Luo (ORCID: https://orcid.org/0000-0003-1400-2130)
- Junfan Zhang
- Jingjing Zuo (ORCID: https://orcid.org/0000-0001-6093-2684)
- Yuanbo Liang
- Xiaojie Wang (ORCID: https://orcid.org/0000-0001-7748-1541)
- Huan Chen (ORCID: https://orcid.org/0000-0003-4125-0666)
- Jiaqian Li (ORCID: https://orcid.org/0000-0001-6655-6069)
- Xuanli Zheng
- Fengping Zhao
- Haishuang Lin (ORCID: https://orcid.org/0000-0002-5750-917X)
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Anhui Provincial Children's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1167/iovs.66.14.60
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00