Chromosomal miscarriage and pregnancy outcomes in recurrent pregnancy loss

Women with unexplained recurrent miscarriage often wonder whether their history will affect future natural pregnancies. Chromosomal abnormalities in embryos are a leading cause of miscarriage, but the impact of such a history on later outcomes has remained unclear. We studied 233 women with repeated unexplained losses and assessed their subsequent pregnancy results. Overall, 73.4% achieved a live birth, while 26.6% had another early miscarriage. Interestingly, among women who had one chromosomal abnormal miscarriage, 85.5% subsequently achieved a live birth. In contrast, the live birth rate was lower in the group who had a normal chromosomal miscarriage; only 61.0% went on to achieve a live birth. These results suggest that a history of abnormal chromosomal miscarriage may indicate better chances of future pregnancy and help guide clinical care.