Urinary metabolome at birth in patients with hypoxic–ischemic encephalopathy treated with therapeutic hypothermia and long-term neurodevelopmental outcomes: a 7-year follow up
The identified metabolites are implicated in neuromodulation and neuronal susceptibility to damage, suggesting their potential as prognostic markers for long-term outcomes in HIE and warranting further investigation. This is the first study linking the acute-phase metabolomic profile with long-term neurodevelopmental outcomes in HIE neonates, supporting its prognostic potential.
Authors
- Paola Pirillo (ORCID: https://orcid.org/0000-0002-1564-3960)
- Claudio Ancona (ORCID: https://orcid.org/0009-0000-5721-5270)
- Ignazio D’Errico (ORCID: https://orcid.org/0000-0002-2942-0151)
- Enrico Valerio (ORCID: https://orcid.org/0000-0001-7454-157X)
- Nicoletta Mainini (ORCID: https://orcid.org/0000-0002-3049-8634)
- Matteo Stocchero (ORCID: https://orcid.org/0000-0001-9296-8390)
- Stefano Sartori (ORCID: https://orcid.org/0000-0002-0012-6848)
- Giuseppe Giordano (ORCID: https://orcid.org/0000-0002-6752-0428)
- Chiara Lasagni
- Alessio Favali
Institutions
- University of Padua (IT)
- Azienda Ospedale - Università Padova (IT)
- Città della Speranza Foundation (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12967-025-06714-w
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Padova