Microbial Consortia-Immunoglobulin G Glycosylation Combination Scores Identify Severe Hepatic Steatosis and Significant Fibrosis in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease
The study highlights the effectiveness of combining fecal microbiota and serum IgG glycosylation features in identifying MASLD severity, which are noninferior to the current regularly used models, and suggests the intervention of glycosylation as a promising therapeutic approach for MASLD.
Authors
- Ying‐Ying Yang (ORCID: https://orcid.org/0000-0002-7719-0397)
- Chien‐Wei Su (ORCID: https://orcid.org/0000-0003-3889-7004)
- Tzu‐Hao Li (ORCID: https://orcid.org/0000-0002-5510-0282)
- Hsiao‐Chin Shen (ORCID: https://orcid.org/0000-0001-8637-2937)
- Jhen‐Wei Ruan (ORCID: https://orcid.org/0000-0002-0636-1937)
- Yi‐Hsuan Lin (ORCID: https://orcid.org/0000-0001-9309-2423)
- Pei-Chen Chen
- Tsui-Ling Hsu (ORCID: https://orcid.org/0000-0002-2912-3261)
- Shiao‐Ya Hong (ORCID: https://orcid.org/0000-0003-4302-1509)
- Chao Ma (ORCID: https://orcid.org/0000-0003-1444-4668)
- Han-Chieh Lin
- Ming‐Chih Hou
- Hsiao-Yun Yeh
- Shin‐Yu Tsai
- Hung-Cheng Tsai
Institutions
- Fu Jen Catholic University (TW)
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- Genomics Research Center, Academia Sinica (TW)
- Taipei City Hospital (TW)
- Memorial Hospital (US)
- National Cheng Kung University (TW)
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.14309/ctg.0000000000000957
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00