Risk of Coronary Artery Disease Associated With Transitions in Metabolic Health in a Clinical Cohort of 69 272
In a large clinical cohort, the transition to metabolic dysfunction is common, occurs rapidly, and significantly increases incident CAD risk. The effect of body weight and weight loss on CAD risk is nonlinear. Interventions to prevent progression to metabolic dysfunction are needed.
Authors
- Joshua A. Beckman (ORCID: https://orcid.org/0000-0001-8332-8439)
- Rebecca T. Levinson (ORCID: https://orcid.org/0000-0002-2775-7543)
- Shi Huang (ORCID: https://orcid.org/0000-0003-2674-2830)
- Heidi J. Silver (ORCID: https://orcid.org/0000-0003-2237-4903)
- Eric Farber‐Eger (ORCID: https://orcid.org/0000-0003-0281-3796)
- Nancy Jean Cox (ORCID: https://orcid.org/0000-0001-9315-0830)
- Frank E. Harrell (ORCID: https://orcid.org/0000-0002-8271-5493)
- Nancy J. Brown (ORCID: https://orcid.org/0000-0001-7109-3142)
- Quinn S. Wells (ORCID: https://orcid.org/0000-0003-3899-0313)
- Megan M. Shuey (ORCID: https://orcid.org/0000-0003-2866-3562)
- Kevin D. Niswender (ORCID: https://orcid.org/0000-0001-6994-8738)
- Alyssa H. Hasty (ORCID: https://orcid.org/0000-0001-7302-8045)
- John R. Koethe (ORCID: https://orcid.org/0000-0001-6490-6942)
- Megan Vogel (ORCID: https://orcid.org/0000-0002-1950-6699)
- Jonathan D. Brown (ORCID: https://orcid.org/0000-0002-0359-6167)
Institutions
- Vanderbilt University (US)
- VA Tennessee Valley Healthcare System (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1161/jaha.124.037597
- Citations
- 1
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 1.29