Panax ginseng alleviates diabetic peripheral neuropathy by suppressing mitochondrial dysfunction and oxidative stress via modulation of the RAGE, NF-κB, and Nrf2 pathways
The findings of this study illustrate that GS mitigates DPN through a synergistic modulation of mitochondrial function, oxidative stress, neuroinflammation, and apoptosis pathways, with particularly significant effects on maintaining Schwann cell and Neuron cell functionality. Our results provide mechanistic insights that advocate for the repurposing of whole GS extract as a multitarget therapeutic agent for managing diabetic complications.
Authors
- Yao Song (ORCID: https://orcid.org/0000-0003-1699-759X)
- Qingxia Shi (ORCID: https://orcid.org/0000-0003-4291-5607)
- Jie Zhang (ORCID: https://orcid.org/0000-0001-8719-698X)
- Pengcheng Liu (ORCID: https://orcid.org/0000-0003-3277-4978)
- Xin Yu (ORCID: https://orcid.org/0000-0002-0166-7494)
- Bang Su (ORCID: https://orcid.org/0009-0004-9254-6461)
- Teng Chih Yang
Institutions
- Jilin University (CN)
- Tissue Regeneration Systems (United States) (US)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1016/j.jgr.2025.09.003
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00