Differences in Anti-αvβ6 Integrin Antibody Expression between U.S. and Japanese Cohorts in Inflammatory Bowel Disease
Anti-αvβ6 is a valuable biomarker for UC diagnosis. However, this study demonstrated differences in its behavior between U.S. and Japanese cohorts, particularly in CD. Cohort-informed interpretation and combined antibody testing may improve diagnostic precision and disease stratification in IBD.
Authors
- Shaohong Yang
- Philip Debbas (ORCID: https://orcid.org/0000-0002-7220-2117)
- Hideya Iwaki
- Soshi Okazaki
- Yoichi Kakuta (ORCID: https://orcid.org/0000-0002-7042-009X)
- Dermot McGovern (ORCID: https://orcid.org/0000-0001-5621-759X)
- Takeo Naito (ORCID: https://orcid.org/0000-0002-9744-7946)
- Masatake Kuroha (ORCID: https://orcid.org/0000-0001-7614-9977)
- Yoshitaka Kinouchi (ORCID: https://orcid.org/0000-0002-3368-8855)
- Atsushi Masamune (ORCID: https://orcid.org/0000-0001-7184-7282)
- Hiroshi Fujii (ORCID: https://orcid.org/0000-0002-6885-6492)
- Yusuke Shimoyama (ORCID: https://orcid.org/0009-0005-1133-7754)
- Hisashi Shiga (ORCID: https://orcid.org/0000-0001-6623-2603)
- Tsuyoshi Shirai (ORCID: https://orcid.org/0000-0002-6295-3494)
- Motoi Sawahashi
- Dalin Li (ORCID: https://orcid.org/0000-0003-4738-0074)
- Hiroshi Nagai (ORCID: https://orcid.org/0000-0002-3779-9085)
- Daisuke Okamoto
- Rintaro Moroi
Institutions
- Cedars-Sinai Medical Center (US)
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- Cedars-Sinai Smidt Heart Institute (US)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/ibd/izaf246
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Cedars-Sinai Medical Center
- Ministry of Health, Labour and Welfare
- Japan Society for the Promotion of Science