Fibrinogen drives neuroinflammation and neuropathology in perioperative neurocognitive disorders
Our study identifies fibrinogen-CD11b signaling as a critical mediator driving age-dependent neuroinflammation and neuropathology in PND. Targeting of this signaling may represent a therapeutic intervention for PND. Our findings link vascular leakage and neuroimmune activation, providing mechanistic insights for PND intervention strategies.
Authors
- Sufang Jiang
- Lichao Di
- Sha Li (ORCID: https://orcid.org/0000-0002-4869-3809)
- Huan Chen (ORCID: https://orcid.org/0000-0003-1182-3144)
- Tianyu Cao
- Peiying Huang
- Lining Huang (ORCID: https://orcid.org/0000-0001-5754-2706)
- Wei Jin (ORCID: https://orcid.org/0000-0002-8578-3731)
- Xueji Wang
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei General Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.intimp.2025.115906
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00