Preventing the onset of diabetes with precision delivery of mesenchymal stem cells to the pancreas in a preclinical model
Local IA delivery of AD-MSCs into the pancreatic circulation effectively prevents the onset of diabetes in a preclinical rat model, highlighting the need for considering delivery techniques to ensure MSCs can reach their targets in vivo.
Authors
- Shashank Chetty (ORCID: https://orcid.org/0000-0003-3563-2748)
- Simranjeet Kaur (ORCID: https://orcid.org/0000-0003-0490-1028)
- Rosita Primavera (ORCID: https://orcid.org/0000-0002-6039-5679)
- Flemming Pociot (ORCID: https://orcid.org/0000-0003-3274-5448)
- Reza Yarani (ORCID: https://orcid.org/0000-0002-9892-1937)
- Martin Haupt‐Jorgensen (ORCID: https://orcid.org/0000-0003-4088-5862)
- Avnesh S. Thakor (ORCID: https://orcid.org/0000-0001-7395-0515)
- Jing Wang (ORCID: https://orcid.org/0000-0001-7989-936X)
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1186/s13287-025-04807-3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lundbeckfonden
- H. Lundbeck A/S
- National Institute of Diabetes and Digestive and Kidney Diseases
- Stanford Maternal and Child Health Research Institute