Clinical validation of a three-marker methylation panel to detect CIN3+ in vaginal self-samples in the Dutch population-based screening programme
Compared to cytology triage testing, DNA methylation triage analysis using our three-marker panel offers an appropriate alternative to detect CIN3+ in hrHPV-positive vaginal self-samples. Implementation of the DNA methylation triage test would not only increase cancer detection, but would also eliminate the need for physician visits for cytological triage testing. In addition, it would accelerate referral decisions, ultimately reducing uncertainty and ensuring timely screening completion for all women.
Authors
- Martha D. Esajas (ORCID: https://orcid.org/0000-0003-0396-3120)
- Jolien de Waard (ORCID: https://orcid.org/0000-0002-0191-9225)
- Karin M. Vermeulen (ORCID: https://orcid.org/0000-0001-9257-2791)
- G. Bea A. Wisman (ORCID: https://orcid.org/0000-0002-4830-3401)
- Geertruida H. de Bock (ORCID: https://orcid.org/0000-0003-3104-4471)
- Arkajyoti Bhattacharya (ORCID: https://orcid.org/0000-0003-1479-0739)
- Ed Schuuring
- Bettien M. van Hemel
- Marieke T. de Boer (ORCID: https://orcid.org/0009-0008-0634-4740)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1186/s13148-025-02020-w
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00