Circulating Tumor Cells and Clinical Outcomes in Men with Metastatic Castration-sensitive Prostate Cancer Treated with Enzalutamide and Docetaxel: An Analysis of the ENZADA Trial

For men with metastatic prostate cancer treated with hormone therapies and chemotherapy, we looked at whether the level of tumor cells circulating in the blood (CTCs) was associated with the PSA (prostate-specific antigen) response and survival time. The CTC level was checked before treatment and after six doses of chemotherapy. We found no association with prostate cancer outcomes. However, in the group of patients whose PSA became undetectable after treatment, a CTC increase after chemotherapy identified men with a higher risk of cancer progression and death.