KlebPhaCol: a community-driven resource for <i>Klebsiella</i> research identified a novel phage family

The growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search for new treatments, including bacteriophage therapy. Despite increasing documentation of Klebsiella-targeting phages, clinical applications remain limited, with key phage-bacteria interactions still poorly understood. A major obstacle is fragmented access to well-characterised phage-bacteria pairings, restricting the collective advancement of therapeutic and mechanistic insights. To address this gap, we created the Klebsiella Phage Collection (KlebPhaCol), an open resource comprising 52 phages and 74 Klebsiella isolates, characterised at phenotypic and genomic levels. These phages span six families-including a novel family, Felixviridae, associated with the human gut-and target 20 sequence types (including ST258, ST11, and ST14) and 19 capsular-locus types (including KL1 and KL2), across 6 Klebsiella species. Freely accessible at www.klebphacol.org, KlebPhaCol invites the scientific community to both use and contribute to this resource, fostering collaborative research and a deeper understanding of Klebsiella-phage interactions beyond therapeutic use.

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Publication Details

Journal
Nucleic Acids Research
Published
2025-11-13
DOI
https://doi.org/10.1093/nar/gkaf1122
Citations
1
Primary Topic
Bacteriophages and microbial interactions
Type
article
Field-Weighted Citation Impact
1.72

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article

KlebPhaCol: a community-driven resource for Klebsiella research identified a novel phage family

Moritz Ertelt, Pieter‐Jan Haas, Peter R. Braun, Franklin L. Nóbrega et al.
1 citations
Nucleic Acids Research
Bacteriophages and microbial interactions
1.72
article

KlebPhaCol: a community-driven resource for Klebsiella research identified a novel phage family

Moritz Ertelt, Pieter‐Jan Haas, Peter R. Braun, Franklin L. Nóbrega, Stephen Mark Edward Fordham, Yi Wu, Simran Krishnakant Kushwaha, Kordo Saeed, Isabella De Angelis, Eugene V. Koonin, Elizabeth Sheridan, Agnieszka Łątka, Daniela Rothschild-Rodriguez, Stan J. J. Brouns, Ana Rita Costa, Yves Briers, Sofya K. Garushyants, Matthew E. Wand, Morgen Hedges, J. Mark Sutton, Dimitri Boeckaerts, Peter Weigele, Francis Drobniewski, Yan‐Jiun Lee, Madeline S. Martin, Anna Mantzouratou, Sophie T Lawson, M Andrew, Claire King, Kai S Lambon, Francesca Merrick
article en
1 citations

Abstract

The growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search for new treatments, including bacteriophage therapy. Despite increasing documentation of Klebsiella-targeting phages, clinical applications remain limited, with key phage-bacteria interactions still poorly understood. A major obstacle is fragmented access to well-characterised phage-bacteria pairings, restricting the collective advancement of therapeutic and mechanistic insights. To address this gap, we created the Klebsiella Phage Collection (KlebPhaCol), an open resource comprising 52 phages and 74 Klebsiella isolates, characterised at phenotypic and genomic levels. These phages span six families-including a novel family, Felixviridae, associated with the human gut-and target 20 sequence types (including ST258, ST11, and ST14) and 19 capsular-locus types (including KL1 and KL2), across 6 Klebsiella species. Freely accessible at www.klebphacol.org, KlebPhaCol invites the scientific community to both use and contribute to this resource, fostering collaborative research and a deeper understanding of Klebsiella-phage interactions beyond therapeutic use.

Nucleic Acids ResearchVol. 53(21)
New England Biolabs (United States) (US), HOGENT University of Applied Sciences and Arts (BE), Defence Science and Technology Laboratory (GB), King's College - North Carolina (US), King's College London (GB), University of Wrocław (PL), Wrocław University of Environmental and Life Sciences (PL), United States National Library of Medicine (US), Ghent University Hospital (BE), Southampton General Hospital (GB), University Medical Center Utrecht (NL), LMU Klinikum (DE), Ghent University (BE), Fraunhofer Institute for Translational Medicine and Pharmacology (DE), University of Southampton (GB), Imperial College London (GB), Ludwig-Maximilians-Universität München (DE), Bournemouth University (GB), Delft University of Technology (NL)
Johns Hopkins University, University Hospital Southampton NHS Foundation Trust, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires
Openalex Percentile: Top 12%
Bacteriophages and microbial interactions
1.72
DOIOpen Access PDFOpenAlex
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