Three-Month cART Initiated During Primary HIV Does Not Correct the Structural, Immune, and Microbial Abnormalities within the Gastrointestinal Tract
Despite early initiation, 12-week cART is unable to correct the HIV-mediated gut damage. Since gut injury drives systemic inflammation, which in turn fosters the pathogenesis of non-communicable comorbidities, our findings provide pathogenetic evidence of limited efficacy of early cART in reverting the HIV-associated pro-inflammatory signature and clinical risk.
Authors
- Delfina Tosi (ORCID: https://orcid.org/0000-0002-6130-2665)
- Andrea Santoro (ORCID: https://orcid.org/0000-0001-7959-2958)
- Carlo Pescia (ORCID: https://orcid.org/0000-0003-0657-506X)
- Giuseppe Ancona (ORCID: https://orcid.org/0000-0002-8506-5115)
- Roberta Rovito (ORCID: https://orcid.org/0000-0002-8640-844X)
- Valentina Sala (ORCID: https://orcid.org/0000-0002-2283-2807)
- Camilla Tincati (ORCID: https://orcid.org/0000-0002-3083-2962)
- Andrea Calcagno (ORCID: https://orcid.org/0000-0003-2534-8815)
- Stefano Rusconi (ORCID: https://orcid.org/0000-0002-0375-9990)
- Monica Falleni (ORCID: https://orcid.org/0000-0002-7905-1227)
- Umberto Gianelli (ORCID: https://orcid.org/0000-0003-3304-8417)
- Andrea Gori (ORCID: https://orcid.org/0000-0001-6587-4794)
- Silvia Nozza (ORCID: https://orcid.org/0000-0002-2673-2731)
- Alessandra Bandera (ORCID: https://orcid.org/0000-0001-9440-4601)
- Matteo Augello (ORCID: https://orcid.org/0000-0002-1031-9504)
- Antonio Muscatello (ORCID: https://orcid.org/0000-0002-2428-6432)
- Valeria Bono (ORCID: https://orcid.org/0000-0003-2182-5434)
- Giulia Bruna Marchetti (ORCID: https://orcid.org/0000-0001-9847-5570)
Institutions
- AOL (United States) (US)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Luigi Sacco Hospital (IT)
- Ospedale Amedeo di Savoia (IT)
- Ospedale San Paolo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- ASST Fatebenefratelli Sacco (IT)
- Azienda Ospedaliera Ospedale Civile di Legnano (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Turin (IT)
Publication Details
- Journal
- Pathogens and Immunity
- Published
- 2025-11-13
- DOI
- https://doi.org/10.20411/pai.v10i2.864
- Primary Topic
- HIV/AIDS oral health manifestations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute