A large-sample analysis of vitamin B12 deficiency anemia, the red cell distribution width, and prostate cancer: identification of their causal relationships, shared gene signatures, and key biological mechanisms
Genetic liability to VB12 deficiency anemia and higher RDW showed modest, directionally consistent associations with increased PCa risk. This risk may be mediated through B3GAT1 and SIK2.
Authors
- Jiaqi Li (ORCID: https://orcid.org/0009-0004-3393-5774)
- Jiaxuan Li (ORCID: https://orcid.org/0000-0002-6146-9780)
- Jing Li (ORCID: https://orcid.org/0000-0002-5450-8155)
- Jinyu Zhang (ORCID: https://orcid.org/0000-0002-9200-5348)
- Qiu Yan (ORCID: https://orcid.org/0000-0003-4253-4126)
- Yubo Zhang (ORCID: https://orcid.org/0000-0002-4121-8853)
- Weijie Zhu (ORCID: https://orcid.org/0009-0000-0830-8331)
Institutions
- Jilin University (CN)
- Jilin Medical University (CN)
- Second Affiliated Hospital of Jilin University (CN)
Publication Details
- Journal
- The Aging Male
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1080/13685538.2025.2588093
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00