Long-term outcomes of benznidazole treatment in chronic Chagas disease: A 27-year cohort study of parasitological cure and death in the Jequitinhonha Valley, Brazil
The overall analysis demonstrated that BZ-T chronic CD patients yielded higher parasitological cure rates as well as increased survival over a 27-year follow-up. The Chagas-Flow ATE proved to be a valuable tool for monitoring therapeutic response and, together with parasitological and molecular parasitological methods, provided a more accurate cure criterion.
Authors
- G. A. Fernandes
- Olindo Assis Martins‐Filho (ORCID: https://orcid.org/0000-0002-5494-4889)
- Gláucia Diniz Alessio (ORCID: https://orcid.org/0000-0001-7853-0886)
- Marta de Lana (ORCID: https://orcid.org/0000-0002-1565-4707)
- Rosália Morais Tôrres (ORCID: https://orcid.org/0000-0003-0466-4130)
- Joana Assis (ORCID: https://orcid.org/0000-0002-9234-7161)
- Mariângela Carneiro (ORCID: https://orcid.org/0000-0002-9390-7714)
- Helen Rodrigues Martins (ORCID: https://orcid.org/0000-0002-5786-7524)
- Girley Francisco Machado-de-Assis
- Renato Afonso Salgado
- Lourena Tomazelli Suave
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Universidade Federal de Ouro Preto (BR)
- Universidade Federal de Minas Gerais (BR)
- Universidade Vale do Rio Doce (BR)
- Hospital Nossa Senhora das Graças (BR)
- Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR)
- Empresa de Pesquisa Agropecuária de Minas Gerais (BR)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1371/journal.pntd.0013619
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00