First-in-Human Biodistribution and Dosimetry of [11C]Trimethoprim
[<sup>11</sup>C]TMP PET was safe and demonstrated low background uptake in most tissues. The data suggests feasibility for evaluation of varied bacterial infections, including musculoskeletal infections. Absorbed doses allow multiple [<sup>11</sup>C]TMP PET scans each year within Radioactive Drug Research Committee (RDRC) limits, potentially enabling monitoring of infections and treatment response.
Authors
- Supritha Dugyala
- J. Cho
- Robert H. Mach (ORCID: https://orcid.org/0000-0002-7645-2869)
- Jonathan M. Pham (ORCID: https://orcid.org/0000-0002-4617-5143)
- Robert K. Doot (ORCID: https://orcid.org/0000-0003-1747-239X)
- Alvaro A. Ordoñez (ORCID: https://orcid.org/0000-0002-8571-0655)
- Austin R. Pantel (ORCID: https://orcid.org/0000-0001-8649-9970)
- Andres Fernandez del Castillo (ORCID: https://orcid.org/0000-0002-1139-5760)
- Anthony J. Young (ORCID: https://orcid.org/0000-0003-3209-1034)
- Mark A. Sellmyer (ORCID: https://orcid.org/0000-0002-1407-1905)
- Tiffany Dominguez
- Erin K. Schubert (ORCID: https://orcid.org/0000-0002-1039-6403)
- David A. Mankoff (ORCID: https://orcid.org/0000-0002-6971-5413)
- Hsiaoju S. Lee (ORCID: https://orcid.org/0000-0001-9082-8618)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1007/s11307-025-02064-7
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania