Efficacy of a multi-clade inactivated recombinant vaccine against the circulating highly pathogenic influenza A/H5N1 of clade 2.3.4.4b in poultry
Commercial inactivated vaccines improved the clinical picture of H5N1 in challenged birds.The developed vaccines induced protective antibody titres against HPAIV clade 2.3.4.4b within 4 weeks.The developed vaccines provided full protection against challenge by HPAIV clade 2.3.4.4b.The developed vaccines provided a significant reduction in virus shedding.
Authors
- Abdulhafez Selim (ORCID: https://orcid.org/0009-0000-6116-6854)
- Amany Adel (ORCID: https://orcid.org/0000-0003-3462-667X)
- Ibrahim Ali
- Walid H. Kilany (ORCID: https://orcid.org/0000-0002-4242-507X)
- Marwa Safwat
- Ahmed Sedeek (ORCID: https://orcid.org/0000-0002-2812-2363)
- Magdy F. El‐Kady (ORCID: https://orcid.org/0000-0003-2976-6598)
- Mohamed A. Zain El‐Abideen (ORCID: https://orcid.org/0000-0001-7336-7733)
- Wael K. Elfeil (ORCID: https://orcid.org/0000-0001-6777-982X)
- Abdel-Satar Arafa (ORCID: https://orcid.org/0000-0001-6370-2526)
- Islam Hisham (ORCID: https://orcid.org/0000-0002-6480-5591)
- Manal A. Afifi
- Momtaz Shaheen
- Heba Hassan (ORCID: https://orcid.org/0000-0003-2822-7947)
Institutions
- Beni-Suef University (EG)
- Suez Canal University (EG)
- Cairo University (EG)
- Animal Health Research Institute (TW)
- Agricultural Research Center (EG)
- King Salman International University
- International University (KH)
- Middle East University (JO)
Publication Details
- Journal
- Avian Pathology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1080/03079457.2025.2582672
- Citations
- 1
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35