The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-κB pathway
Our findings reveal that R-2HG specifically inhibits microglial inflammatory activation by suppressing the FTO/NF-κB signaling pathway, leading to decreased IL-6 production. This study provides a novel mechanism by which R-2HG modulates the tumor immune microenvironment, which may be beneficial for exploring the basis of antitumor immunity in IDH-mutant gliomas.
Authors
- Yulan Qian
- Yuanchi Huang (ORCID: https://orcid.org/0009-0001-3421-7123)
- X. M. Jing (ORCID: https://orcid.org/0000-0002-0200-3008)
- Yong Kang (ORCID: https://orcid.org/0000-0003-0991-5314)
- Huiting Zhang
- Lu Wang (ORCID: https://orcid.org/0000-0002-4165-4022)
- Dong Chen (ORCID: https://orcid.org/0000-0002-9581-8774)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fonc.2025.1525761
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00