Clinical application and impact of metagenomic next-generation sequencing for the diagnosis of infectious diseases in severely immunocompromised pediatric patients
mNGS exhibited superior diagnostic performance compared to CMT for diagnosing infections in critically ill children. More than half (66.0%) of mNGS tests resulted in a positive clinical impact on diagnosis and treatment, particularly among ICH patients.
Authors
- Weiguo Yang (ORCID: https://orcid.org/0000-0002-5312-0749)
- Zhenyu Zhang (ORCID: https://orcid.org/0000-0003-4974-1400)
- Huili Shen (ORCID: https://orcid.org/0000-0003-3904-1144)
- Xiaolei Zhang (ORCID: https://orcid.org/0000-0001-9123-0888)
- Weiming Chen
- Panpan Fan (ORCID: https://orcid.org/0000-0001-9340-3383)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3483-8990)
- Guoping Lü (ORCID: https://orcid.org/0000-0002-6815-4554)
- Liming He
- Yixue Wang (ORCID: https://orcid.org/0009-0005-5596-8507)
- Bin Yang (ORCID: https://orcid.org/0000-0001-6180-7412)
- Bingxue Hu (ORCID: https://orcid.org/0000-0001-9116-6249)
- Gangfeng Yan
Institutions
- Vision Medicals (China) (CN)
- Shenzhen Children's Hospital (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12887-025-06338-5
- Citations
- 1
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.80