High-Fidelity Transcriptome Reconstruction of Degraded RNA-Seq Samples Using Denoising Diffusion Models
DiffRepairer is a validated, high-precision tool for transcriptome repair that effectively restores biologically meaningful signals from degraded RNA-seq data, highlighting the potential of advanced generative models in bioinformatics.
Authors
- Jinlei Sun (ORCID: https://orcid.org/0009-0009-9194-2282)
- Hengchuan Guo
- Chen Li (ORCID: https://orcid.org/0000-0002-7386-8981)
- Ke Xiao (ORCID: https://orcid.org/0000-0002-0169-4185)
- Yajun Pang (ORCID: https://orcid.org/0000-0002-4752-1036)
- Zhiyu Liu (ORCID: https://orcid.org/0000-0002-1678-5960)
- Yiying Wang (ORCID: https://orcid.org/0000-0002-0889-2520)
- Yunqing Liu (ORCID: https://orcid.org/0000-0003-3515-2314)
Institutions
- Nanjing Normal University (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Luoyang Institute of Science and Technology (CN)
- Southeast University (CN)
Publication Details
- Journal
- Biology
- Published
- 2025-11-23
- DOI
- https://doi.org/10.3390/biology14121652
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00