MiR-503-5p mediates cell cycle arrest and fibrosis of peritoneal mesothelial cells with a high peritoneal solute transport status
Patients with PD who had a high PSTR exhibited an elevated inflammatory state, and the presence of inflammatory factors stimulated the upregulation of miR-503-5p expression, which led to cell cycle arrest in PMCs and promoted peritoneal fibrosis development.
Authors
- Yan Tong (ORCID: https://orcid.org/0000-0002-7610-8259)
- Ouyang Ji
- Yunyao Lin
- Yingxin Xie
- Pu Li (ORCID: https://orcid.org/0000-0002-0327-6542)
- Yingli Liu (ORCID: https://orcid.org/0000-0001-8464-7917)
- Junyan Fang
- Ruolin Li
Institutions
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12882-025-04587-1
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00