Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization
By integrating MR, replication, meta-analysis, PWAS, and PPI, our findings genetically nominate IL27RA, IL17RD, and TIE1 as putative candidates for therapeutic investigation and/or biomarker development in COPD. Further mechanistic and pharmacological studies are required before any treatment claims can be made.
Authors
- Jiangfeng Xiao
- Qinyao Jia
- Shan Song (ORCID: https://orcid.org/0000-0002-2841-2213)
- Yong Li (ORCID: https://orcid.org/0000-0001-7956-9600)
- Wenbo Zhang (ORCID: https://orcid.org/0000-0002-8694-2554)
- Tao Wang (ORCID: https://orcid.org/0000-0003-1341-9372)
- Chunlei Yu
Institutions
- North Sichuan Medical University (CN)
- Chongqing University (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12890-025-04006-z
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Sichuan Province
- Sanming Project of Medicine in Shenzhen