3D Breast Cancer Spheroids Reveal Architecture-Dependent HER2 Expression and Signaling
3D architecture profoundly influences HER2 distribution, signaling, and structural organization in HER2+ BCa spheroids. This model provides a robust platform for investigating architecture-dependent molecular processes, with potential applications in drug response, receptor trafficking, and targeted therapy evaluation.
Authors
- Maria Cristina Gagliani (ORCID: https://orcid.org/0000-0002-2902-2719)
- Grazia Bellese
- Paola Orecchia (ORCID: https://orcid.org/0000-0003-0556-9784)
- Pietro Arnaldi (ORCID: https://orcid.org/0000-0003-0274-8525)
- Patrizio Castagnola (ORCID: https://orcid.org/0000-0003-2008-9199)
- Katia Cortese (ORCID: https://orcid.org/0000-0001-9218-8933)
- Valentina Delli Zotti
Institutions
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Biology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3390/biology14121654
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Università degli Studi di Genova
- Ministero dell'Università e della Ricerca